What is primary amebic meningoencephalitis ?
The kidneys are a pair of organs in the abdomen that perform many important functions in the human body, including: Filtering blood: The kidneys remove waste products and extra water from the blood, which is then excreted as urine. Balancing chemicals: The kidneys help maintain a healthy balance ofRead more
The kidneys are a pair of organs in the abdomen that perform many important functions in the human body, including:
Filtering blood: The kidneys remove waste products and extra water from the blood, which is then excreted as urine.
Balancing chemicals: The kidneys help maintain a healthy balance of chemicals like sodium, potassium, calcium, and phosphorus in the blood.
Regulating blood pressure: The kidneys release hormones that help control blood pressure.
Stimulating red blood cell production: The kidneys produce hormones that stimulate the bone marrow to make red blood cells.
Maintaining pH balance: The kidneys help keep the body’s pH stable by reabsorbing and producing bicarbonate from urine.
Activating vitamin D: The kidneys help activate vitamin D from diet and sunlight to keep bones and muscles healthy.
Making glucose: The kidneys make sugar (glucose) if the blood doesn’t have enough sugar.
The kidneys are located below the ribs toward the middle of the back.


Primary amebic meningoencephalitis (PAM) is a rare, usually fatal brain infection caused by the amoeba Naegleria fowleri. This free-living amoeba is commonly found in warm freshwater environments like lakes, rivers, and hot springs, as well as in poorly maintained pools or contaminated water supplieRead more
Primary amebic meningoencephalitis (PAM) is a rare, usually fatal brain infection caused by the amoeba Naegleria fowleri. This free-living amoeba is commonly found in warm freshwater environments like lakes, rivers, and hot springs, as well as in poorly maintained pools or contaminated water supplies.
PAM occurs when the amoeba enters the body through the nose, typically during activities like swimming or diving. From there, it travels to the brain, causing severe inflammation of the brain and its surrounding membranes (meningoencephalitis). Symptoms usually start within 1–9 days and include headache, fever, nausea, vomiting, stiff neck, confusion, seizures, and coma. The infection progresses rapidly, often leading to death within days if untreated.
Diagnosis is challenging and typically involves detecting the amoeba in cerebrospinal fluid or brain tissue, often confirmed posthumously. Treatment is difficult due to the rapid progression and limited effective drugs, but regimens may include antifungal and antimicrobial agents like amphotericin B, miltefosine, and others, with supportive care. Survival is rare, with only a few documented cases globally.
Prevention focuses on avoiding exposure: using nose clips while swimming in warm freshwater, ensuring proper pool maintenance, and avoiding untreated water for nasal irrigation. The CDC and WHO emphasize that PAM is not contagious and cannot be contracted from drinking contaminated water.
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