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bhawnaguptaBeginner
Asked: 5 days agoIn: , , ,
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Which is a genetic inability to metabolize the amino acid phenylalanine?

Which is a genetic inability to metabolize the amino acid phenylalanine?

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  1. Pankaj Gupta
    Pankaj Gupta Scholar

    The genetic inability to metabolize the amino acid phenylalanine is known as Phenylketonuria (PKU). Phenylketonuria (PKU) Cause: It is caused by a mutation in the gene that encodes the enzyme phenylalanine hydroxylase (PAH), which is essential for converting phenylalanine into tyrosine. Effect: WithRead more

    The genetic inability to metabolize the amino acid phenylalanine is known as Phenylketonuria (PKU).

    Phenylketonuria (PKU)

    • Cause: It is caused by a mutation in the gene that encodes the enzyme phenylalanine hydroxylase (PAH), which is essential for converting phenylalanine into tyrosine.
    • Effect: Without this enzyme, phenylalanine accumulates in the body, leading to toxic levels that can cause brain damage and intellectual disabilities if not managed.
    • Inheritance: PKU is an autosomal recessive disorder, meaning a person must inherit two copies of the mutated gene (one from each parent) to develop the condition.
    • Management: It is managed by a strict diet low in phenylalanine, starting in infancy, to prevent the harmful effects of the amino acid buildup.

    Newborns are routinely screened for PKU as part of standard neonatal screening programs in many countries.

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bhawnagupta
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bhawnaguptaBeginner
Asked: 2 months agoIn:
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What are grap restrictions?

What are grap restrictions?

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  1. Vaishnavi
    Vaishnavi Explorer
    GRAP restrictions

    GRAP Stage 3 entails a ban on non-essential construction work. Classes up to grade V are required to shift to hybrid mode under Stage 3. Parents and students have the option to choose online education wherever available. Under Stage 3, the use of BS-III petrol and BS-IV diesel cars (4-wheelers) is rRead more

    GRAP Stage 3 entails a ban on non-essential construction work. Classes up to grade V are required to shift to hybrid mode under Stage 3. Parents and students have the option to choose online education wherever available.

    Under Stage 3, the use of BS-III petrol and BS-IV diesel cars (4-wheelers) is restricted in Delhi and nearby NCR districts. Persons with disabilities are exempt.

    Stage 3 also bans non-essential diesel-operated medium goods vehicles with BS-IV or older standards in Delhi. The Stage 3 of GRAP was lifted on December 27 after a marked improvement in Delhi’s air quality following day-long rainfall in the national capital.

    Throughout 2024, Delhi recorded the highest number of ‘severe’ AQI days since 2022, with 17 days exceeding an AQI of 400. Additionally, 70 days were classified as ‘very poor’. Not a single ‘good’ air quality day was recorded in 2024, a first since 2018.

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bhawnagupta
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bhawnaguptaBeginner
Asked: 2 months agoIn:
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Is it possible to prepare for UPSC while doing PhD?

Is it possible to prepare for UPSC while doing PhD?

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  1. Pankaj Gupta
    Pankaj Gupta Scholar

    Yes, it is possible to prepare for the UPSC Civil Services Examination (CSE) while pursuing a PhD, but it requires careful planning, time management, and dedication. Here are some considerations and tips for balancing both: 1. Understand the Commitment Required for Both PhD: A PhD demands significanRead more

    Yes, it is possible to prepare for the UPSC Civil Services Examination (CSE) while pursuing a PhD, but it requires careful planning, time management, and dedication. Here are some considerations and tips for balancing both:

    1. Understand the Commitment Required for Both

    • PhD: A PhD demands significant time for research, experiments, thesis writing, and meetings with your supervisor.
    • UPSC Preparation: It requires comprehensive coverage of a vast syllabus, consistent answer writing practice, and staying updated with current affairs.

    2. Assess Your Schedule

    • Determine how much free time you have after meeting your PhD responsibilities. Utilize evenings, weekends, and holidays effectively for UPSC preparation.
    • If your PhD work is highly demanding, consider pacing your UPSC preparation over a longer duration.

    3. Leverage Overlapping Areas

    • If your PhD subject aligns with any of the UPSC optional subjects or General Studies (e.g., Political Science, Geography, Sociology), it can reduce the preparation burden.
    • Use your research skills to dive deeper into relevant topics and enhance your understanding of complex issues.

    4. Follow a Structured Plan

    • Set Realistic Goals: Divide the UPSC syllabus into manageable sections and assign specific timelines.
    • Prioritize Topics: Focus on high-yield areas such as Polity, Economy, History, Geography, and Current Affairs.
    • Daily Routine: Dedicate fixed hours daily to UPSC preparation, even if it’s only 2–3 hours.

    5. Utilize Available Resources

    • Opt for online classes or self-study materials if you cannot attend coaching due to your PhD schedule.
    • Use mobile apps, podcasts, and YouTube channels to study during short breaks or while commuting.

    6. Stay Updated

    • Allocate time daily to read newspapers like The Hindu or Indian Express and follow a reliable current affairs magazine.

    7. Answer Writing and Test Series

    • Start practicing answer writing for Mains and attempting mock tests early, as this will help you internalize the syllabus and improve your presentation skills.

    8. Manage Stress

    • Balancing a PhD and UPSC preparation can be stressful. Incorporate activities like exercise, meditation, or hobbies to maintain mental well-being.

    9. Take Guidance

    • Seek advice from mentors or peers who have attempted UPSC during a PhD. Their experiences can offer valuable insights.

    10. Flexibility and Backup Plan

    • Be prepared for delays in completing your PhD or not clearing UPSC in your first attempt. Have a backup plan for your career.

    Real-Life Examples

    Several candidates such as Anna Sinha have successfully cleared UPSC while pursuing higher studies, including PhDs. Their success underscores the importance of discipline and a strategic approach.

    With proper planning and perseverance, it is feasible to balance both pursuits effectively.

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bhawnagupta
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bhawnaguptaBeginner
Asked: 6 months agoIn:
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What is the difference between Psychological contract violation and Psychological contract breach?

What is the difference between Psychological contract violation and Psychological contract breach?

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  1. Pankaj Gupta
    Pankaj Gupta Scholar

    The concepts of psychological contract breach and psychological contract violation are related but distinct within the field of organizational behavior and human resources. Here's a breakdown of the differences: Psychological Contract Breach A psychological contract breach occurs when an employee peRead more

    The concepts of psychological contract breach and psychological contract violation are related but distinct within the field of organizational behavior and human resources. Here’s a breakdown of the differences:

    Psychological Contract Breach

    A psychological contract breach occurs when an employee perceives that the organization has failed to fulfill one or more obligations or promises made, either explicitly or implicitly.

    • Characteristics
      • Perception-Based: It is the employee’s perception that the employer has not met its commitments.
      • Cognitive Reaction: The breach is often a cognitive recognition that something promised has not been delivered.
      • Less Intense: The emotional reaction may not be strong. Employees might feel disappointed or concerned, but the reaction is more about the discrepancy between expectations and reality.
    • For Example: An employee expected a promotion after a year of service based on conversations during the hiring process, but the promotion did not happen. The employee perceives this as a breach of the psychological contract.

     

    Psychological Contract Violation

    A psychological contract violation is the emotional and affective response that arises when an employee perceives a severe breach of the psychological contract. It goes beyond the recognition of unmet expectations to include strong emotional reactions.

    • Characteristics
      • Emotional Response: It involves a deeper emotional response, such as anger, betrayal, or resentment.
      • Affective Reaction: The violation signifies a significant impact on the employee’s feelings towards the employer.
      • More Intense: The emotional reaction is often more intense and can lead to negative behaviors such as reduced loyalty, increased turnover intention, or decreased job performance.
    • For Example: Using the same scenario of an unfulfilled promotion promise, the employee not only perceives the breach but also feels deeply betrayed and angry, leading to a significant decline in their trust and commitment to the organization.
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